This report examines the social determinants of health (SDOH), underscoring that environmental and social factors are the primary determinants of health outcomes. Significant barriers to healthcare access include high insurance costs and a large uninsured population, contributing to Florida’s low national ranking in healthcare access. Challenges are particularly acute in rural and low-income areas, with a notable dependence on emergency services by uninsured individuals, imposing considerable economic strains. To address these issues, the report suggests expanding Medicaid eligibility to enhance access and reduce costs, promoting telehealth to connect urban and rural communities, increasing autonomy for nurse practitioners and physician assistants to alleviate physician shortages, and implementing the “Live Healthy Agenda” to elevate healthcare quality and access throughout Florida. These recommendations aim to catalyze systemic changes for a healthier, economically stable state.